selected publications
2026
- Wang, J., Pelissier, A., Lin, JSH (...) Johnson, JD., Penninger, JM. (2026). Organotypic vascularization improves maturation of human stem cell-derived islets and restores normoglycemia in diabetic mice.Cell Stem Cell. 2026 Oct 16:S1934-5909(26)00353-X.
- Hagelkruys, A., Stein, E., Mosca, E (...) Volz-Glaser, J., Penninger, JM. (2026). Generation of a human induced pluripotent stem cell panel from a family with a heterozygous RPS19 mutation including healthy wild-type, silent carrier and Diamond-Blackfan anemia individuals. Stem Cell Res. 2026 Oct;96:104098.
- Jonsson, G., Oliveira, T., Hofmann, M (…) Schmidinger, M., Penninger, JM. (2026). Urinary multi-omics reveal non-invasive diagnostic biomarkers in clear cell renal cell carcinoma. EMBO Mol Med. 2026 Sep;18(9):3649-3676.
- Mereiter, S., Jonsson, G., Oliveira, T (...) Zitvogel, L., Penninger, JM. (2026). Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer. Nat Commun. 2026 May 22;17(1):6760.
- Jonsson, G., Hofmann, M., Mereiter, S (...) Schleiffer, A., Penninger, JM. (2026). CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression. FEBS J. 2026 Feb;293(3):709-728.
2025
- Onji, M., Sigl, V., Lendl, T (...) Koo, BK., Penninger, JM. (2025). RANK drives structured intestinal epithelial expansion during pregnancy. Nature. 637(8044):156-166
- Kellner, MJ., Monteil, VM., Zelger, P (...) Mirazimi, A., Penninger, JM. (2025). Bat organoids reveal antiviral responses at epithelial surfaces. Nat Immunol. 26(6):934-946
- Nikolova, MT., He, Z., Seimiya, M (...) Camp, JG., Treutlein, B. (2025). Fate and state transitions during human blood vessel organoid development. Cell.
2024
- Starkl, P., Jonsson, G., Artner, T (...) Penninger, JM., Cronin, SJF. (2024). Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Sci Immunol. 9(98):eadh0545
- Monteil, VM., Wright, SC., Dyczynski, M (...) Penninger, JM., Mirazimi, A. (2024). Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nat Microbiol.
- Quintard, C., Tubbs, E., Jonsson, G (...) Penninger, JM., Gidrol, X. (2024). A microfluidic platform integrating functional vascularized organoids-on-chip. Nat Commun. 15(1):1452
- Cikes, D., Leutner, M., Cronin, SJF (...) Orthofer, M., Penninger, JM. (2024). Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nat Aging. 4(1):80-94
2023
- Oudit, GY., Wang, K., Viveiros, A., Kellner, MJ., Penninger, JM. (2023). Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic. Cell. 186(5):906-922
- Salewskij, K., Penninger, JM. (2023). Blood Vessel Organoids for Development and Disease.Circ Res. 132(4):498-510
- Taubenschmid-Stowers, J., Orthofer, M., Laemmerer, A (...) Horn, M., Penninger, JM. (2023). A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO Mol Med. 15(3):e16959
- Cikes, D., Elsayad, K., Sezgin, E (...) Banka, S., Penninger, JM. (2023). PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nat Metab. 5(3):495-515
- Monteil, V., Kwon, H., John, L (...) Penninger, JM., Mirazimi, A. (2023). Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections. Nat Commun. 14(1):6785
2022 and before
- Fell, CW., Hagelkruys, A., Cicvaric, A (...) Penninger, JM., Nagy, V. (2022). FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO Mol Med. 14(9):e15829
- Hagelkruys, A., Horrer, M., Taubenschmid-Stowers, J (...) Knoblich, JA., Penninger, JM. (2022). The HUSH complex controls brain architecture and protocadherin fidelity. Sci Adv. 8(44):eabo7247
- Cronin, SJF., Rao, S., Tejada, MA (...) Penninger, JM., Woolf, CJ. (2022). Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Sci Transl Med. 14(660):eabj1531
- Monteil, V., Eaton, B., Postnikova, E (...) Wirnsberger, G., Penninger, JM. (2022). Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. EMBO Mol Med. :e15230
- Garreta, E., Prado, P., Stanifer, ML (...) Penninger, JM., Montserrat, N. (2022). A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Cell Metab.
- Batlle, D., Monteil, V., Garreta, E (...) Bader, M., Penninger, JM. (2022). Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Cell. 185(11):1837-1839
- Gawish, R., Starkl, P., Pimenov, L (...) Penninger, JM., Knapp, S. (2022). ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology. Elife. 11
- Paolino, M., Koglgruber, R., Cronin, SJF (...) Kautzky-Willer, A., Penninger, JM. (2021). RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature. 589(7842):442-447
- Hoffmann, D., Mereiter, S., Jin Oh, Y (...) Hinterdorfer, P., Penninger, JM. (2021). Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. EMBO J. :e108375
- Monteil, V., Kwon, H., Prado, P (...) Mirazimi, A., Penninger, JM. (2020). Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 181(4):905-913.e7
- Orthofer, M., Valsesia, A., Mägi, R (...) Gheldof, N., Penninger, JM. (2020). Identification of ALK in Thinness. Cell. 181(6):1246-1262.e22
- Wimmer, RA., Leopoldi, A., Aichinger, M (...) Kerjaschki, D., Penninger, JM. (2019). Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 565(7740):505-510
- Cronin, SJF., Seehus, C., Weidinger, A (...) Woolf, CJ., Penninger, JM. (2018). The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 563(7732):564-568
- Elling, U., Wimmer, RA., Leibbrandt, A (...) Stark, A., Penninger, JM. (2017). A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. 550(7674):114-118
- Stadlmann, J., Taubenschmid, J., Wenzel, D (...) Mechtler, K., Penninger, JM. (2017). Comparative glycoproteomics of stem cells identifies new players in ricin toxicity. Nature. 549(7673):538-542
- Wirnsberger, G., Zwolanek, F., Asaoka, T (...) Kuchler, K., Penninger, JM. (2016). Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 22(8):915-23
- Sigl, V., Owusu-Boaitey, K., Joshi, PA (...) Jones, LP., Penninger, JM. (2016). RANKL/RANK control Brca1 mutation- . Cell Res. 26(7):761-74
- Paolino, M., Choidas, A., Wallner, S (...) Klebl, BM., Penninger, JM. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507(7493):508-12
- Hanada, T., Weitzer, S., Mair, B (...) Martinez, J., Penninger, JM. (2013). CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495(7442):474-80
- Hashimoto, T., Perlot, T., Rehman, A (...) Rosenstiel, P., Penninger, JM. (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81
- Elling, U., Taubenschmid, J., Wirnsberger, G (...) Stark, A., Penninger, JM. (2011). Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell. 9(6):563-74
- Schramek, D., Leibbrandt, A., Sigl, V (...) Schett, G., Penninger, JM. (2010). Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468(7320):98-102