As the central laboratory of Vienna General Hospital (AKH), the Clinical Institute of Laboratory Medicine at the Medical University of Vienna plays a key role in the provision of laboratory diagnostics at the university hospital.
Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis
Recent technological advancements have led to the discovery of a rich immune cell diversity in atherosclerotic lesions. In a study published July 26 in the prestigious journal Immunity, the team identified a specific subtype of complement-producing macrophages that are present in both mouse as well as human atherosclerotic plaques.
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Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis
Osteoarthritis was long considered to be the result of wear and tear in advanced age. In the meantime, more and more studies are linking the degradation of articular cartilage to inflammatory and metabolic processes in the joint
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Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH
In this study, we demonstrate that TREM2-expressing macrophages are recruited to the liver where they fulfil an important protective function in NASH-related fibrosis - a precursor to liver cirrhosis.
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APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans
Atherosclerotic cardiovascular disease causes heart attacks and strokes, which are the leading causes of mortality worldwide. The formation of atherosclerotic plaques is initiated when low-density lipoproteins bind to heparan-sulfate proteoglycans (HSPGs) and become trapped in the subendothelial space of large and medium size arteries, which leads to chronic inflammation and remodelling of the artery wall
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