Aims
Our goal is to develop new and effective treatments for various diseases by uncovering the fundamental biological principles underlying development and disease.
Approach
Our lab is full of highly motivated and creative scientists. Together we wish to understand the architecture and underlying mechanisms of human disease, with the ultimate aim of identifying novel therapeutic strategies.
To accomplish our goals, we develop and deploy a broad range of in vitro and in vivo tools that reveal the fundamental mechanisms involved in human disease. These approaches include (glyco)proteomics, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, mouse and human organoid cultures, as well as genetically engineered mice. Our multidisciplinary techniques enable us to model and study the complexity of human diseases.
Impact
We take a holistic approach and use novel tools to answer complex biological questions. Our research aims to advance our knowledge of biology, reveal mechanisms that prevent or drive disease and provide opportunities to design new treatment strategies.