Selected Publications
- Ondracek* AS, Afonyushkin* T, et al. Malondialdehyde-specific natural IgM inhibit NETosis triggered by culprit site–derived extracellular vesicles from myocardial infarction patients. European Heart Journal. 2024. doi: 10.1093/eurheartj/ehae584.
- Porsch F and Binder CJ. Autoimmune diseases and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2024. doi: 10.1038/s41569-024-01045-7.
- Jäger R, Hoke M, et al. Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality. J Am Coll Cardiol. 2024;83:1717-1727. doi: 10.1016/j.jacc.2024.02.043.
- Piollet M, Porsch F, et al. TREM2 limits necrotic core formation during atherogenesis by controlling macrophage survival and efferocytosis. bioRxiv. 2023:2023.05.15.539977. doi: 10.1101/2023.05.15.539977
- Kiss M. G.*, Papac-Milicevic N.*, et al. Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis. Immunity. 2023;56:1809-1824 e10. doi: 10.1016/j.immuni.2023.06.026.
- Hendrikx T*, Porsch F*, et al. Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH. J Hepatol. 2022;77(5):1373-1385. doi:10.1016/j.jhep.2022.06.004
- Tsiantoulas, D. et al., 2021, APRIL limits atherosclerosis by binding to heparan-sulfate proteoglycans. Nature 2021 Sep; 597(7874):92-96. https://doi.org/10.1038/s41586-021-03818-3
- Obermayer G*, Afonysuhkin T*, et al. Natural IgM antibodies inhibit microvesicle-driven coagulation and thrombosis. Blood 2020 Dec 9. https://pubmed.ncbi.nlm.nih.gov/33512411/
- Alic L*, Papac-Milicevic N*, et al. A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9942-9951. https://pubmed.ncbi.nlm.nih.gov/32321835/
- Puhm F*, Afonyushkin T*, et al. Mitochondria are a subset of extracellular vesicles released by activated monocytes and induce type I IFN and TNF responses in endothelial cells. Circ Res. 2019;125 (1), 43-52.https://pubmed.ncbi.nlm.nih.gov/31219742/
- Tsiantoulas D, et al. B-Cell-Activating Factor Neutralization Aggravates Atherosclerosis. Circulation. 2018 Nov 13;138(20):2263-2273. https://pubmed.ncbi.nlm.nih.gov/29858401/
- Binder CJ, et al. Innate sensing of oxidation-specific epitopes in health and disease. Nat Rev Immunol. 2016;16(8):485-97. https://pubmed.ncbi.nlm.nih.gov/27346802/
- Gruber S, et al. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep. 2016;14(10):2348-61. https://pubmed.ncbi.nlm.nih.gov/26947073/
- Cardilo-Reis L, et al. Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol Med. 2012 Oct;4(10):1072-86. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491837/
- Weismann D, et al. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011 Oct 5;478(7367):76-81. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826616/
- Chou MY, et al. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May;119(5):1335-49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673862/
- Binder CJ, et al. IL-5 links adaptive and natural immunity specific for epitopes of Oxidized LDL and protects from atherosclerosis. J Clin Invest 2004 Aug; 114(3):427-37. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC484976/
- Binder CJ, et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun;9(6):736-43. http://www.nature.com/nm/journal/v9/n6/full/nm876.html?foxtrotcallback=true